HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyric Acid → HCID 66727564, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyric Acid | HCID 6590 | — |
| Reactant | [(S)-4-(5-amino-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57496584 | — |
| Product | HCID 66727564 | HCID 66727564 | — |
Reaction Steps
The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate F) and isobutyric acid followed by deprotection of the intermediate yielded the title compound as a colorless oil. MS (ESI): m/z=349.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-5d9e44f637af4b6f9e372899f9ec14db |
| Source note | uspto-grants-2014_08 |