4-Amino-3-fluorobenzonitrile → (S)-4-(3-(2-Amino-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydropyrimidin-4-yl)-4-fluorophenylamino)-3-fluorobenzonitrile

Participants

Reaction Steps

The coupling of (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate K) and 4-amino-3-fluoro-benzonitrile according to procedure B followed by deprotection yielded the title compound as an off-white foam. MS (ESI): m/z=398.2 [M+H]+.

Provenance & Evidence