2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → (S)-2-Amino-6-(5-(2,2-dimethyl-2,3-dihydrobenzofuran-7-ylamino)-2-fluorophenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one

Participants

Reaction Steps

The coupling of (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate K) and 2,2-dimethyl-2,3-dihydro-benzofuran-7-ylamine according to procedure B followed by deprotection yielded the title compound as an off-white solid. MS (ESI): m/z=425.2 [M+H]+.

Provenance & Evidence