HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one → HCID 57497034, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde | HCID 57497168 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | HCID 57497034 | HCID 57497034 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 4-chloro-1-difluoromethyl-1H-pyrazole-3-carbaldehyde using decaborane yielded (S)-2-amino-6-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one as colorless solid. MS (ESI): m/z=443.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9ad4b1ea7db74f83bd91ff8130746452 |
| Source note | uspto-grants-2014_08 |