HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3-chlorobenzonitrile → HCID 57516126, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3-chlorobenzonitrile | HCID 519896 | — |
| Reactant | (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497159 | — |
| Product | HCID 57516126 | HCID 57516126 | — |
Reaction Steps
The coupling of (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate K) and 4-amino-3-chloro-benzonitrile according to procedure B followed by deprotection yielded the title compound as a white solid. MS (ESI): m/z=414.1 and 416.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-bea907a6b7d343acb99e3bcd80a052fd |
| Source note | uspto-grants-2014_08 |