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HRID2409228

反应详情

EQUATION

反应方程式

HRID 2409228 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(OCC(F)(F)F)nc1
HCID543156

6-(2,2,2-trifluoroethoxy)pyridin-3-amine

C7H7F3N2O

结构：COc1ccc(C(NC2=N[C@](C)(c3cc(Br)ccc3F)C(C)(C)C(=O)N2C)(c2ccccc2)c2ccc(OC)cc2)cc1
HCID57497159

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3ccc(OCC(F)(F)F)nc3)ccc2F)N=C1N
HCID57497025

未命名化合物

PROCEDURE

实验过程

The coupling of (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate K) and 6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine according to procedure B followed by deprotection yielded the title compound as an off-white foam. MS (ESI): m/z=454.2 [M+H]+.