Hydrochloric Acid → N4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyrimidine-2,4-diamine

Participants

Reaction Steps

88 mg of {4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-ylamino]-pyrimidin-2-yl}-carbamic acid tert-butyl ester (cf. EXAMPLE 8a) were treated with 6 ml 4 m HCl in dioxane at ambient temperature for 4 hrs. After evaporation the product was digerated with ether and isolated by filtration to give 57 mg of N4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyrimidine-2,4-diamine as hydrochloride salt with Rt˜1.36 min and correct mass found M+H˜367.

Provenance & Evidence