Methylamine → HCID 53372462, compound

Participants

Reaction Steps

14.4 mg 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-ylamino]-nicotinic acid methyl ester were treated with 250 μl of 33% methylamine in ethanol at 40° C. for 5 min and then at ambient temperature for 16 hrs. After evaporation the product was digerated with ether and dried to give 15.7 mg 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-ylamino]-N-methyl-nicotinamide as a yellowish powder with Rt˜1.47 min and correct mass M+H˜408.

Provenance & Evidence