Tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate → HCID 67361368, compound

HRID 2409263Notes

Reaction equation

HRID 2409263 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][CH3:16])[C:10]=2[N+:17]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24]>C(O)C.[Pd]>[NH2:17][C:10]1[C:11]([NH:15][CH3:16])=[N:12][CH:13]=[CH:14][C:9]=1[O:8][C:6]1[CH:5]=[CH:4][C:3]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:26])[CH3:24])=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 1

HCID 57507628Tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

Product 1

HCID 67361368HCID 67361368, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate (5.3 mg, 14 mmol) was dissolved in absolute ethanol (600 mL) and hydrogenated on a 10% Pd/C cartridge through an H-Cube apparatus, to give the title compound as a yellow solid.

Sources & evidence

ORD record
ord-7b81377769934f71b5347a91456e07c4
Source dataset
uspto-grants-2014_08
Patent number
US08815896B2

Reaction notes

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