Ethylamine → HCID 71178913, compound

HRID 2409270Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:21]=[CH:22][C:23]=2[S:24](O)(=[O:26])=[O:25])[C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH3:20])=[O:5])[CH3:2].[CH2:28]([NH2:30])[CH3:29]>>[CH2:28]([NH:30][S:24]([C:23]1[CH:22]=[N:21][N:10]2[C:11]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[CH3:20])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8][C:9]=12)(=[O:26])=[O:25])[CH3:29]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 86681882HCID 86681882, compound

Product 1

HCID 71178913HCID 71178913, compoundYield 33.3%

Procedure

Using 6-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.500 g, 1.268 mmol) obtained in Example 1 step 2 and ethylamine (2.0 mol/L THF solution; 2.5 mL, 5.071 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (0.178 g, 33%) was obtained.

Sources & evidence

ORD record: ord-27021b2f8a604e5c9f926eb3024f963d
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815874B2

Reaction notes

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