4-(4-Fluoro-phenyl)-piperidine hydrochloride → HCID 53379325, compound

HRID 2409271Notes

Reaction equation

HRID 2409271 reaction equation
[CH2:1]([NH:3][S:4]([C:7]1[CH:8]=[N:9][N:10]2[C:15]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=3[CH3:24])=[C:14]([C:25](OCC)=[O:26])[CH:13]=[N:12][C:11]=12)(=[O:6])=[O:5])[CH3:2].Cl.[F:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:34][CH:33]=1>>[CH2:1]([NH:3][S:4]([C:7]1[CH:8]=[N:9][N:10]2[C:15]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=3[CH3:24])=[C:14]([C:25]([N:41]3[CH2:42][CH2:43][CH:38]([C:35]4[CH:34]=[CH:33][C:32]([F:31])=[CH:37][CH:36]=4)[CH2:39][CH2:40]3)=[O:26])[CH:13]=[N:12][C:11]=12)(=[O:5])=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 218981684-(4-Fluoro-phenyl)-piperidine hydrochlorideHCID 71178913HCID 71178913, compound

Product 1

HCID 53379325HCID 53379325, compoundYield 7.9%

Procedure

Using ethyl 3-(N-ethylsulfamoyl)-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.483 g, 1.145 mmol) obtained in Example 2 step 1 and 4-(4-fluorophenyl)piperidine hydrochloride (0.099 g, 0.458 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.020 g, 3%) was obtained.

Sources & evidence

ORD record
ord-c14bbb587c95415fb992a3b6485ae39c
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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