Ethanamine, 2,2,2-trifluoro- → HCID 71178916, compound

HRID 2409272Notes

Reaction equation

HRID 2409272 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:21]=[CH:22][C:23]=2[S:24](O)(=[O:26])=[O:25])[C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH3:20])=[O:5])[CH3:2].[F:28][C:29]([F:33])([F:32])[CH2:30][NH2:31]>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:11]2[N:10]3[N:21]=[CH:22][C:23]([S:24](=[O:26])(=[O:25])[NH:31][CH2:30][C:29]([F:33])([F:32])[F:28])=[C:9]3[N:8]=[CH:7][C:6]=2[C:4]([O:3][CH2:1][CH3:2])=[O:5])=[C:14]([CH3:20])[CH:15]=1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 86681882HCID 86681882, compound

Product 1

HCID 71178916HCID 71178916, compoundYield 87.6%

Procedure

Using 6-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.970 g, 2.460 mmol) obtained in Example 1 step 2 and 2,2,2-trifluoroethylamine (0.975 g, 9.838 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (1.024 g, 87%) was obtained.

Sources & evidence

ORD record
ord-355c71c0177145939d3e8a1b121e39f8
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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