4-(4-Fluoro-phenyl)-piperidine hydrochloride → HCID 53379326, compound

HRID 2409273Notes

Reaction equation

HRID 2409273 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18](=[O:26])(=[O:25])[NH:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:13]3[N:12]=[CH:11][C:10]=2[C:27](OCC)=[O:28])=[C:4]([CH3:32])[CH:3]=1.Cl.[F:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)=[CH:37][CH:36]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18]([NH:19][CH2:20][C:21]([F:22])([F:23])[F:24])(=[O:25])=[O:26])=[C:13]3[N:12]=[CH:11][C:10]=2[C:27]([N:44]2[CH2:45][CH2:46][CH:41]([C:38]3[CH:37]=[CH:36][C:35]([F:34])=[CH:40][CH:39]=3)[CH2:42][CH2:43]2)=[O:28])=[C:4]([CH3:32])[CH:3]=1

Participants

3

Reactant 2

HCID 218981684-(4-Fluoro-phenyl)-piperidine hydrochlorideHCID 71178916HCID 71178916, compound

Product 1

HCID 53379326HCID 53379326, compoundYield 21%

Procedure

Using ethyl 7-(4-fluoro-2-methylphenylamino)-3-[N-(2,2,2-trifluoroethyl)sulfamoyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.142 g, 0.298 mmol) obtained in step 1 and 4-(4-fluorophenyl)piperidine hydrochloride (0.072 g, 0.335 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.028 g, 21%) was obtained.

Sources & evidence

ORD record
ord-118a4406c5fb4cbca13ff9f4b15ade95
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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