Cyclopropylamine → HCID 71178961, compound

HRID 2409274Notes

Reaction equation

HRID 2409274 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:21]=[CH:22][C:23]=2[S:24]([OH:27])(=[O:26])=O)[C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH3:20])=[O:5])[CH3:2].[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][S:24]([C:23]2[CH:22]=[N:21][N:10]3[C:11]([NH:12][C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=4[CH3:20])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8][C:9]=23)(=[O:26])=[O:27])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 86681882HCID 86681882, compound

Product 1

HCID 71178961HCID 71178961, compoundYield 100%

Procedure

Using 6-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.400 g, 1.145 mmol) obtained in Example 1 step 2 and cyclopropylamine (0.261 g, 4.580 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (0.496 g, 100%) was obtained.

Sources & evidence

ORD record
ord-a1bd3bab1484455b8a453e9397fb4dbe
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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