4-(4-Fluorophenyl)piperidine → HCID 71179005, compound

HRID 2409279Notes

Reaction equation

HRID 2409279 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])=[C:16]([C:26]([O:28]CC)=O)[CH:15]=[N:14][C:13]=12)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:34][CH:33]=1>>[C:1]([NH:5][S:6]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])=[C:16]([C:26]([N:41]3[CH2:42][CH2:43][CH:38]([C:35]4[CH:34]=[CH:33][C:32]([F:31])=[CH:37][CH:36]=4)[CH2:39][CH2:40]3)=[O:28])[CH:15]=[N:14][C:13]=12)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 71178921HCID 71178921, compound

Product 1

HCID 71179005HCID 71179005, compoundYield 59%

Procedure

Using ethyl 3-(N-tert-butylsulfamoyl)-7-(2-chlorophenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate (4.25 g, 8.82 mmol) obtained in Example 6 step 3 and 4-(4-fluorophenyl)piperidine (1.87 g, 10.46 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (2.42 g, 59%) was obtained.

Sources & evidence

ORD record
ord-caeaf7f1e9904de2a676e012128cad3d
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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