Ethylamine → HCID 71179048, compound

HRID 2409285Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([S:19](O)(=[O:21])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].[CH2:28]([NH2:30])[CH3:29]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([S:19](=[O:20])(=[O:21])[NH:30][CH2:28][CH3:29])=[C:14]2[N:13]=[CH:12][C:11]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 86681884HCID 86681884, compound

Product 1

HCID 71179048HCID 71179048, compoundYield 87.4%

Procedure

Using 7-(2-chloro-5-methylphenylamino)-6-(ethoxycarbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.72 g, 1.75 mmol) obtained in Example 12 step 2 and ethylamine (2.0 mol/L THF solution; 3.5 mL, 7.01 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (0.67 g, 87%) was obtained.

Sources & evidence

ORD record: ord-2ecdbd51532f43f594d96878cd457d07
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815874B2

Reaction notes

Loading…