4-(4-Fluorophenyl)piperidine → HCID 71178936, compound

HRID 2409286Notes

Reaction equation

HRID 2409286 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([S:19](=[O:24])(=[O:23])[NH:20][CH2:21][CH3:22])=[C:14]2[N:13]=[CH:12][C:11]=1[C:25]([O:27]CC)=O.[F:30][C:31]1[CH:36]=[CH:35][C:34]([CH:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[CH:33][CH:32]=1>>[CH2:21]([NH:20][S:19]([C:18]1[CH:17]=[N:16][N:15]2[C:10]([NH:9][C:3]3[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=3[Cl:1])=[C:11]([C:25]([N:40]3[CH2:41][CH2:42][CH:37]([C:34]4[CH:33]=[CH:32][C:31]([F:30])=[CH:36][CH:35]=4)[CH2:38][CH2:39]3)=[O:27])[CH:12]=[N:13][C:14]=12)(=[O:24])=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 71179048HCID 71179048, compound

Product 1

HCID 71178936HCID 71178936, compoundYield 18.2%

Procedure

Using ethyl 7-(2-chloro-5-methylphenylamino)-3-(N-ethylsulfamoyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.084 g, 0.205 mmol) obtained in step 1 and 4-(4-fluorophenyl)piperidine (0.030 g, 0.183 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.019 g, 16%) was obtained.

Sources & evidence

ORD record
ord-5c41d35b1f4d41fe88104034edbc2045
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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