Ethylamine → HCID 71178971, compound

HRID 2409288Notes

Reaction equation

HRID 2409288 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18](O)(=[O:20])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:4]([CH3:27])[CH:3]=1.[CH2:28]([NH2:30])[CH3:29]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18](=[O:19])(=[O:20])[NH:30][CH2:28][CH3:29])=[C:13]3[N:12]=[CH:11][C:10]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:4]([CH3:27])[CH:3]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 86681885HCID 86681885, compound

Product 1

HCID 71178971HCID 71178971, compoundYield 95%

Procedure

Using 7-(4-chloro-2-methylphenylamino)-6-(ethoxycarbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (1.00 g, 2.43 mmol) obtained in step 2 and ethylamine (2.0 mol/L THF solution; 4.9 mL, 9.74 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (1.01 g, 95%) was obtained.

Sources & evidence

ORD record
ord-41feb4c4e5db4cd2bdefd6316f222d70
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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