4-(4-Fluorophenyl)piperidine → HCID 71178966, compound

HRID 2409289Notes

Reaction equation

HRID 2409289 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18](=[O:23])(=[O:22])[NH:19][CH2:20][CH3:21])=[C:13]3[N:12]=[CH:11][C:10]=2[C:24](OCC)=[O:25])=[C:4]([CH3:29])[CH:3]=1.[F:30][C:31]1[CH:36]=[CH:35][C:34]([CH:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[CH:33][CH:32]=1>>[CH2:20]([NH:19][S:18]([C:17]1[CH:16]=[N:15][N:14]2[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=3[CH3:29])=[C:10]([C:24]([N:40]3[CH2:41][CH2:42][CH:37]([C:34]4[CH:33]=[CH:32][C:31]([F:30])=[CH:36][CH:35]=4)[CH2:38][CH2:39]3)=[O:25])[CH:11]=[N:12][C:13]=12)(=[O:22])=[O:23])[CH3:21]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 71178971HCID 71178971, compound

Product 1

HCID 71178966HCID 71178966, compoundYield 6.6%

Procedure

Using ethyl 7-(4-chloro-2-methylphenylamino)-3-(N-ethylsulfamoyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.33 g, 0.77 mmol) obtained in step 3 and 4-(4-fluorophenyl)piperidine (0.26 g, 1.44 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.029 g, 6%) was obtained.

Sources & evidence

ORD record
ord-f09c5306ecfc47968e1f1015228bf821
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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