4-(4-Fluorophenyl)piperidine → HCID 86681886, compound

HRID 2409306Notes

Reaction equation

HRID 2409306 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:21]=[CH:22][C:23]=2[S:24]([OH:27])(=[O:26])=[O:25])[C:11]=1[NH:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[Cl:20])=[O:5])C.[F:28][C:29]1[CH:34]=[CH:33][C:32]([CH:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)=[CH:31][CH:30]=1>>[Cl:20][C:14]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=1[NH:12][C:11]1[N:10]2[N:21]=[CH:22][C:23]([S:24]([OH:27])(=[O:25])=[O:26])=[C:9]2[N:8]=[CH:7][C:6]=1[C:4]([N:38]1[CH2:39][CH2:40][CH:35]([C:32]2[CH:31]=[CH:30][C:29]([F:28])=[CH:34][CH:33]=2)[CH2:36][CH2:37]1)=[O:5]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 86681887HCID 86681887, compound

Product 1

HCID 86681886HCID 86681886, compoundYield 87.1%

Procedure

Using 6-ethoxycarbonyl-7-(2,5-dichlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.5 g, 1.16 mmol) obtained in Example 22 step 2 and 4-(4-fluorophenyl)piperidine (1.42 g, 7.94 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.57 g, 63%) was obtained.

Sources & evidence

ORD record
ord-da1ec6805e954ad5a41b24f183685902
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

Loading…