Propionic Acid → HCID 71178997, compound

HRID 2409311Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[NH:12][C:13]1[N:18]2[N:19]=[CH:20][C:21]([S:22]([NH2:25])(=[O:24])=[O:23])=[C:17]2[N:16]=[CH:15][C:14]=1[C:26]([N:28]1[CH2:33][CH2:32][CH:31]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1)=[O:27].[C:41](O)(=[O:44])[CH2:42][CH3:43]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:9])[F:11])=[CH:4][C:3]=1[NH:12][C:13]1[N:18]2[N:19]=[CH:20][C:21]([S:22]([NH:25][C:41](=[O:44])[CH2:42][CH3:43])(=[O:24])=[O:23])=[C:17]2[N:16]=[CH:15][C:14]=1[C:26]([N:28]1[CH2:33][CH2:32][CH:31]([C:34]2[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=2)[CH2:30][CH2:29]1)=[O:27]

Participants

Reactant 2

HCID 1032Propionic Acid

HCID 71178897HCID 71178897, compound

Product 1

HCID 71178997HCID 71178997, compoundYield 87.5%

Procedure

Using 7-(2-chloro-5-trifluoromethylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide (0.050 g, 0.084 mmol) obtained in step 5 and propionic acid (0.031 mL, 0.419 mmol) instead of cyclopropanecarboxylic acid, and in the same manner as in Example 1 step 6, the title compound (0.048 g, 87%) was obtained.

Sources & evidence

ORD record: ord-60c4a4eaa8a541319aa2309760ceafc5
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815874B2

Reaction notes

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