2-Chloro-5-fluoroaniline → HCID 71179015, compound

HRID 2409312Notes

Reaction equation

HRID 2409312 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:18]=1[NH2:19]>>[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:18]=1[NH:19][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 27365092-Chloro-5-fluoroanilineHCID 178469627HCID 178469627, compound

Product 1

HCID 71179015HCID 71179015, compoundYield 83.9%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (3.5 g, 16.9 mmol) and 2-chloro-5-fluoroaniline (2.21 g, 15.2 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (4.27 g, 75%) was obtained.

Sources & evidence

ORD record
ord-9115f849b8dc4d60a07dc1a7f0968f32
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

Loading…