Acetic Acid → HCID 71178973, compound

HRID 2409320Notes

Reaction equation

HRID 2409320 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:37])=[C:6]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18]([NH2:21])(=[O:20])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:22]([N:24]2[CH2:29][CH2:28][CH:27]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH2:26][CH2:25]2)=[O:23])[CH:7]=1.[C:38](O)(=[O:40])[CH3:39]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:37])=[C:6]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([S:18]([NH:21][C:38](=[O:40])[CH3:39])(=[O:19])=[O:20])=[C:13]3[N:12]=[CH:11][C:10]=2[C:22]([N:24]2[CH2:25][CH2:26][CH:27]([C:30]3[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=3)[CH2:28][CH2:29]2)=[O:23])[CH:7]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 71178946HCID 71178946, compound

Product 1

HCID 71178973HCID 71178973, compoundYield 87.7%

Procedure

Using 7-(5-chloro-2-fluorophenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide (0.050 g, 0.091 mmol) obtained in step 5 and acetic acid (0.026 mL, 0.457 mmol) instead of cyclopropanecarboxylic acid, and in the same manner as in Example 1 step 6, the title compound (0.047 g, 87%) was obtained.

Sources & evidence

ORD record
ord-513c13e28b8e43e6ab99df9b6194f9bd
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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