2-Fluoro-4-methylaniline → HCID 71179027, compound

HRID 2409334Notes

Reaction equation

HRID 2409334 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH3:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1>>[F:24][C:19]1[CH:18]=[C:17]([CH3:16])[CH:23]=[CH:22][C:20]=1[NH:21][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 679842-Fluoro-4-methylanilineHCID 178469627HCID 178469627, compound

Product 1

HCID 71179027HCID 71179027, compoundYield 53.5%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (5.0 g, 24.1 mmol) and 4-methyl-2-fluoroaniline (6.04 g, 48.3 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (4.05 g, 53%) was obtained.

Sources & evidence

ORD record
ord-1303bace374540799ccfeeb10cdf38b9
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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