反应详情

温度

160 °C

To a solution of {1-[2-bromo-4-(pyridine-4-ylcarbamoyl)-phenyl]-ethyl}-carbamic acid tert-butyl ester (1951 μmol) in a mixture of DME/EtOH/2N Na2CO3: 1/1/1 (10 ml) were added 3-carboxymethylphenylboronic acid (1.5 eq) and Pd tetrakis (0.05 eq). The reaction mixture was heated in the microwave at 160° C. for 15 minutes. The reaction mixture was cooled to RT, filtered over celite and washed with EtOAc and MeOH. The solvents were removed under reduced pressure. The compound was purified by column chromatography (silicagel, DCM/MeOH gradient).

1. temperatureThe reaction mixture was cooled to RT
2. filtrationfiltered over celite
3. washwashed with EtOAc and MeOH
4. customThe solvents were removed under reduced pressure
5. customThe compound was purified by column chromatography (silicagel, DCM/MeOH gradient)