Potassium Carbonate → HCID 58425000, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of the compound (873 mg, 2.28 mmol) prepared in step 2 in N,N-dimethylformamide (6.0 ml), were added sequently palladium(II) acetate (153.6 mg, 0.684 mmol), 1,3-bis(diphenylphosphino)propane (282 mg, 0.684 mmol), tributylphosphine (0.563 ml, 2.28 mmol), and potassium carbonate (630 mg, 4.56 mmol) and the mixture was refluxed for four hours at 120° C. Once the reaction was completed, the reaction mixture was cooled to a room temperature and extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash column chromatography (hexane:ethyl acetate:dichloromethane=1:1:1) to obtain the title compound (192.4 mg, yield: 24%, white solid).

Provenance & Evidence