反应详情

To a stirred solution of the compound of 8-methoxy-6-(4-methoxybenzyl)benzo[h][1,6]naphthyridine-5(6H)-one (192.4 mg, 0.555 mmol) prepared in step 3 in ethyl acetate/dichloromethane/methanol, was added 10%-palladium (Pd) (20 mg) and the mixture was stirred for 18 hours under hydrogen gas. Once the reaction was completed, 10%-palladium (Pd) was filtered out, and the filtrate was concentrated under reduced pressure to obtain the title compound (192.7 mg, yield: 99%, ivory solid).

1. filtration10%-palladium (Pd) was filtered out
2. concentrationthe filtrate was concentrated under reduced pressure