1-Bromopropane → HCID 58424956, compound

Participants

Reaction Conditions

Reaction Steps

Compound (55 mg, 0.17 mmol) prepared in step 4 and potassium carbonate (70 mg, 0.50 mmol) were dissolved in acetonitrile (10 ml), added with 1-bromopropane (53 μl, 0.058 mol) at room temperature. The resulting mixture was stirred overnight at 60° C. and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was then purified by flash column chromatography (chloroform:methanol=5:1) to obtain the title compound (34 mg, yield: 61%, white solid).

Provenance & Evidence