1,4-Dioxane hydrochloride → HCID 58424943, compound

HRID 2409409Notes

Reaction equation

HRID 2409409 reaction equation
[CH3:1][N:2]1[C:11]2[C:10]3[CH:12]=[C:13]([O:16][CH:17]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]4)[CH:14]=[CH:15][C:9]=3[NH:8][C:7](=[O:30])[C:6]=2[CH2:5][CH2:4][CH2:3]1.O1CCOCC1.Cl>O1CCOCC1>[CH3:1][N:2]1[C:11]2[C:10]3[CH:12]=[C:13]([O:16][CH:17]4[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]4)[CH:14]=[CH:15][C:9]=3[NH:8][C:7](=[O:30])[C:6]=2[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58424890HCID 58424890, compound

Product 1

HCID 58424943HCID 58424943, compoundYield 105.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (70 mg, 0.17 mmol) prepared in step 1 was dissolved in 1,4-dioxane (3 ml), added with 3.7 N hydrochloric acid 1,4-dioxane solution. The resulting mixture was stirred overnight at room temperature and the precipitate was collected by filtration to obtain the title compound (56 mg, yield: 86%, brown solid).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-5ac26afe3c6045f7a351e0839173491c
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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