Sodium Hydroxide → HCID 58424937, compound

Participants

Reaction Steps

The compound (200 mg, 0.51 mmol) prepared in step 3 of Example 5 was dissolved in methanol, added with 1 N sodium hydroxide (5 ml). The resulting mixture was refluxed for 18 hours cooled to room temperature. The mixture was concentrated under reduced pressure and added with water. Water layer was acidified with 1 N hydrochloric acid and extracted with ethylacetat. The organic layer was dried over anhydrous magnesium sulfate and concentrated to dryness. With no separate purification process, title compound (140 mg, yield: 76%, white solid) was obtained.

Provenance & Evidence