Potassium Iodide → HCID 58424875, compound

Participants

Reaction Steps

The compound (60 mg, 0.234 mmol) prepared in step 5 was dissolved in N,N-dimethylformamide (5 ml), added with potassium carbonate (161 mg, 1.17 mmol) and potassium iodide (8 mg, 0.047 mmol). After stirring for 30 minutes, N,N-dimethylaminoethyl chloride hydrochloride was added at room temperature and the resulting mixture was stirred for one more day at 70° C. The mixture was extracted chloroform, dried over anhydrous magnesium sulfate, concentrated to dryness. The residue was then purified by flash column chromatography (chloroform:methanol=10:1) to obtain the title compound (40 mg, yield: 53%, white solid).

Provenance & Evidence