Imidazole → HCID 11391885, compound

Participants

Reaction Steps

4-nitrophenethylalcohol (1.0 g, 5.98 mmol) was dissolved in tetrahydrofuran (20 ml), sequentially added with t-butyldimethylsilyl chloride (990 mg, 6.58 mmol) and imidazole (450 mg, 6.58 mmol). The resulting mixture was stirred for one day and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated to dryness. The residue was then purified by flash column chromatography (ethylacetate:hexane=1:8) to obtain the title compound (1.65 g, yield: 98%, yellow oil).

Provenance & Evidence