Chloromethyl Methyl Ether → HCID 58424857, compound

Participants

Reaction Steps

The compound (100 mg, 0.31 mmol) prepared in step 2 was dissolved in N,N-dimethylformamide (3 ml), added with sodium hydride (407 mg, 10.02 mmol) at 0° C. After stirring for 30 minutes, chloromethyl methyl ether was added dropwise and the resulting mixture was stirred for 8 hours. The mixture was poured into ice water and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and concentrated to dryness. The residue was then purified by flash column chromatography (hexane:ethyl acetate=2:1) to obtain title compound (57 mg, yield: 50%, yellow liquid).

Provenance & Evidence