Water → HCID 58424845, compound

Participants

Reaction Steps

The compound (55 mg, 0.146 mmol) prepared in step 3 was dissolved in N,N-dimethylformamide (3 ml), sequentially added with palladium(II) acetate (9.83 mg, 0.0438 mmol), 1,3-bis(dephenylphosphino)propane (18 mg, 0.0438 mmol), tributylphosphine (0.036 ml, 0.146 mmol), and potassium carbonate (40 mg, 0.292 mmol). The resulting mixture was refluxed for 5 hours. Water was added to the above solution and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated to dryness. The residue was then purified by flash column chromatography (hexane:ethyl acetate=3:1) to obtain title compound (31 mg, yield: 64%, white solid).

Provenance & Evidence