Hydrochloric Acid → HCID 58424880, compound

Participants

Reaction Steps

The compound (151 mg, 0.51 mmol) prepared in step 7 was dissolved in methanol, sequentially added with 2 M dimethylamine (2.18 ml, 4.38 mmol), sodium cyanoborohydride (35 mg, 0.56 mmol), zinc chloride(II) (35 mg, 0.255 mmol), and 1.25 M hydrochloric acid (2.44 ml, 3.06 mmol) at 0° C. The resulting mixture was stirred for one hour at room temperature. The mixture was poured into ice water and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated to dryness. The residue was then purified by flash column chromatography (chloroform:methanol=15:1) to obtain the title compound (152 mg, yield: 92%, white solid).

Provenance & Evidence