2-Chloro-N,N-dimethylethylamine → HCID 58424930, compound

Participants

Reaction Conditions

Reaction Steps

8-hydroxy-6-(methoxymethyl)benzo[h][1,6]naphthyridine-5(6H)-one (58 mg, 0.22 mmol) and potassium carbonate (94 mg, 0.67 mmol) were dissolved in N,N-dimethylformamide (5 ml) and added with 2-(dimethylamino)ethyl chloride (39 mg, 0.0.27 mmol). The resulting mixture was stirred for 2 hours at 90° C. and poured into ice water. The mixture was extracted with chloroform, dried over anhydrous sodium sulfate, and concentrated to dryness. The residue was then purified by flash column chromatography (chloroform:methanol=6:1) to obtain the title compound (53 mg, yield: 73%, white solid).

Provenance & Evidence