Dimethyl-1,3-thiazole-5-sulfonyl chloride → N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)-2,4-dimethylthiazole-5-sulfonamide
Reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])[C:5]([NH2:18])=[CH:4][CH:3]=1.[CH3:19][C:20]1[S:21][C:22]([S:26](Cl)(=[O:28])=[O:27])=[C:23]([CH3:25])[N:24]=1>>[F:8][C:7]1[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])=[C:5]([NH:18][S:26]([C:22]2[S:21][C:20]([CH3:19])=[N:24][C:23]=2[CH3:25])(=[O:28])=[O:27])[CH:4]=[CH:3][C:2]=1[F:1]Participants
3
Procedure
According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine (0.182 mmol) was reacted with 2,4-dimethylthiazole-5-sulfonyl chloride (0.5 mmol) to obtain N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)-2,4-dimethylthiazole-5-sulfonamide. 1H NMR (300 MHz, CDCl3)) δ 23 (s, 3H), 2.6 (s, 3H), 5.7 (s, 1H), 5.9 (dt, 1H), 7.1 (q, 1H), 7.2 (d, 1H), 7.3 (m, 1H), 7.4 (d, 1H), 7.4 (s, 1H).
Sources & evidence
- ORD record
- ord-ac557a366034446fbb29f5b1d86925e9
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648116B2
Reaction notes
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