Water → HCID 58424897, compound

Participants

Reaction Steps

The compound (1.11 g, 2.94 mmol) prepared in step 5 was dissolved in N,N-dimethylformamide (10.0 ml), added with palladium(II) acetate (215 mg, 0.881 mmol), 1,3-bis(dephenylphosphino)propane (363 mg, 0.881 mmol), tributylphosphine (0.724 ml, 2.94 mmol), and potassium carbonate (812 mg, 5.87 mmol). The resulting mixture was refluxed for 3 hours and cooled to room temperature. Water and dichloromethane were added and the mixture was extracted. The organic layer was dried over anhydrous magnesium sulfate and concentrated to dryness. The residue was then purified by flash column chromatography (dichloromethane:ethyl acetate=4:1) to obtain the title compound (776.5 mg, yield: 77.3%, white solid).

Provenance & Evidence