HCID 58424897, compound → HCID 58424908, compound

Participants

Reaction Steps

The compound (776.5 mg, 2.27 mmol) prepared in step 6 was dissolved in dichloromethane and methanol, added with 10%-palladium (Pd) (80.0 mg). The resulting mixture was stirred at room temperature for 20 hours under hydrogen gas. After completion, 10%-palladium (Pd) was removed by celite-filter and the solvent was concentrated under reduced pressure. The residue was then purified by flash column chromatography (dichloromethane:ethyl acetate=3:1) to obtain the title compound (458 mg, yield: 58.2%, white solid).

Provenance & Evidence