Ammonium Chloride → HCID 58424901, compound

Participants

Reaction Conditions

Reaction Steps

Tetrahydrofuran (10.0 ml) was added to lithium aluminum hydride (125 mg, 3.30 mmol) and cooled to 0° C. The compound (457 mg, 1.32 mmol) prepared in step 7 was dissolved in tetrahydrofuran (10.0 ml) was added dropwise slowly at 0° C. and the resulting mixture was stirred at the same temperature for 1 hour. After completion, ammonium chloride aqueous solution was added and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and concentrated to dryness. The residue was then purified by flash column chromatography (dichloromethane:methanol=10:1) to obtain the title compound (399 mg, yield: 99.2%, ivory solid).

Provenance & Evidence