Ammonium Chloride → HCID 178496774, compound

Participants

Reaction Steps

The compound (65 mg, 0.23 mmol) prepared in step 1 was dissolved in N,N-dimethylformamide (5 ml), sequentially added with sodium azide (75 mg, 1.15 mmol) and ammonium chloride (61 mg, 1.15 mmol). The resulting mixture was refluxed for 48 hours and cooled to room temperature. The mixture was washed with chloroform and the water layer was concentrated to dryness. The residue was then washend with methanol and filtered. The filtrate was purified by flash column chromatography (chloroform:methanol=5:1) to obtain the title compound (34 mg, yield: 45%, yellow solid).

Provenance & Evidence