N-Aminomorpholine → HCID 87378600, compound

Participants

Reaction Steps

The compound (95 mg, 0.31 mmol) prepared in step 1 was dissolved in toluene (10 ml), added with 4-aminomorpholine (0.031 ml, 0.31 mmol) at room temperature. The resulting mixture was then heated and allowed to reflux under dean-stark condenser for 5 hours. After cooling to room temperature, the solivent was removed under reduced pressure and the residue was purified by flash column chromatography (dichloromethane:methanol=20:1) to obtain the title compound (109 mg, yield: 89%, yellow solid).

Provenance & Evidence