Sodium cyanoborohydride → HCID 67381226, compound

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Reaction Steps

The compound (50 mg, 0.12 mmol) prepared in step 2 was dissolved in tetrahydrofuran (2 ml), added with sodium cyanoborohydride (4 mg, 0.06 mmol) and 1.25 N hydrochloric acid methanol solution (5 ml) slowly. The resulting mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove the solvent. The residue was basified with 1 N sodium hydroxide aqueous solution and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and the solvent was concentrated to dryness. The residue was then purified by flash column chromatography (dichloromethane:methanol=20:1) to obtain the title compound (18 mg, yield: 38%, yellow solid).

Provenance & Evidence