Methyl iodide → HCID 67381073, compound

Participants

Reaction Steps

The compound (40 mg, 0.10 mmol) prepared in step 3 of Example 96 and potassium carbonate (22 mg, 0.15 mmol) were dissolved in acetonitrile (5 ml), added with iodo methane (0.008 ml, 0.12 mmol). The resulting mixture was heated to reflux temperature and stirred for 18 hours. The reaction mixture was poured into ice water and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was then purified by flash column chromatography (dichloromethane:methanol=15:1) to obtain the title compound (3 mg, yield: 8%, yellow solid).

Provenance & Evidence