Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Bromothiophene-2-sulfonyl chloride → 5-Bromo-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Bromothiophene-2-sulfonyl chloride | HCID 2733924 | — |
| 반응물 | 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine | HCID 59386306 | — |
| 생성물 | 5-Bromo-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide | HCID 59386377 | — |
반응 단계
According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene 1,2-diamine was reacted with 5-bromothiophene-2-sulfonyl chloride to obtain the title compound. 1H NMR (300 MHz, CDCl3): δ 7.39-7.29 (m, 2H), 7.20-7.05 (m, 3H), 6.96 (d, J=3.6 Hz, 1H), 5.85 (dt, J=2.1, 9.0 & 17.4 Hz, 1H), 5.54 (br s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648116B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-a8dcb2fa0d88427fa10d6cef237d1867 |
| 출처 메모 | uspto-grants-2014_02 |