HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R,4S)-4-Aminotetrahydro-2H-pyran-3-ol → 4-[(6-chloropyridin-3-yl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-5,6,7,8-tetrahydroquinoline-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R,4S)-4-Aminotetrahydro-2H-pyran-3-ol | HCID 54180780 | — |
| Reactant | 1,5-anhydro-3-[({4-[(6-chloropyridin-3-yl)methyl]-5,6,7,8-tetrahydroquinolin-2-yl}carbonyl)amino]-2,3-dideoxy-L-threo-pentitol | HCID 54767345 | — |
| Product | 4-[(6-chloropyridin-3-yl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-5,6,7,8-tetrahydroquinoline-2-carboxamide | HCID 54767346 | — |
Reaction Steps
4-[(6-Chloropyridin-3-yl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-5,6,7,8-tetrahydroquinoline-2-carboxamide was prepared by the procedure described for the synthesis of 1,5-anhydro-3-[({4-[(6-chloropyridin-3-yl)methyl]-5,6,7,8-tetrahydroquinolin-2-yl}carbonyl)amino]-2,3-dideoxy-L-threo-pentitol in Example 1, substituting (1S,2S)-2-aminocyclohexanol for (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815902B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-8744e3e3a0ca4398975a1ab722b6e688 |
| Source note | uspto-grants-2014_08 |