Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

4-{4-[5-(6-Amino-5-trifluoromethyl-pyridin-3-yl) -imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-2-methoxy-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester (23 mg; 0.039 mmol; 1 eq) was suspended in anhydrous DCM (3 ml) and 4M HCl in 1,4-dioxane (0.097 ml, 0.39 mmol, 10 eq) was added. The reaction mixture was stirred at RT overnight. The solvents were removed and the residue was co-evaporated with DCM (×3). The residue was triturated in CH3CN and filtered to give the desired product as HCl salt (19 mg, 92%). HPLC-MS (5-100% B in 8 min at 0.8 mL): tR=3.25 min, [M+H]+ m/z 491.2; 1H NMR (300 MHz, DMSO) δ 9.10 (s, 2H), 8.88 (s, 1H), 8.49 (d, J=1.6 Hz, 1H), 7.87 (s, 1H), 7.53 (m, 2H), 7.31 (d, J=9.1 Hz, 1H), 4.76 (s, 1H), 3.91 (s, 3H), 3.17 (m, 2H), 3.09 (m, 2H), 2.12 (m, 2H), 1.90 (m, 2H).

Provenance & Evidence