Sodium Thiosulfate → HCID 66716934, compound

Participants

Reaction Steps

3-(trifluoromethyl)-5-(imidazo[2,1-b][1,3,4]thiadiazol-2-yl)pyridin-2-amine (0.244 g, 0.855 mmol, 1 eq) was dissolved in DMF (5 mL), and NIS (0.212 g, 0.941 mmol, 1.1 eq) was added. The reaction mixture was stirred at RT under N2 for 18 h and then poured into an aqueous solution of sodium thiosulfate (10%) and extracted with AcOEt. The organic phase was separated, washed with ice-water and ammonium chloride, dried (Na2SO4), filtered and evaporated to dryness. The residue was treated with Et2O, filtered off and dried affording the desired product (0.240 g, 68%). HPLC-MS (10-95% B in 4 min at 0.5 mL+2 min 100% B, flow 0.8 mL/min, 50° C.): tR=4.27 min, [M+H]+ m/z 411.9.

Provenance & Evidence