3-Phenylpropylamine → Ethyl 5-{[(3-phenylpropyl)amino]methyl}-2-furoate

HRID 2409599Notes

Reaction equation

HRID 2409599 reaction equation
[CH:1]([C:3]1[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1)=O.[C:13]1([CH2:19][CH2:20][CH2:21][NH2:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH2:19][CH2:20][CH2:21][NH:22][CH2:1][C:3]2[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 162593-PhenylpropylamineHCID 15589950Ethyl 5-formylfuran-2-carboxylate

Product 1

HCID 68106142Ethyl 5-{[(3-phenylpropyl)amino]methyl}-2-furoate

Procedure

Subsequently, ethyl 5-{[(3-phenylpropyl)amino]methyl}-2-furoate (0.64 g) was prepared from ethyl 5-formyl-furan-2-carboxylate (500 mg) and 3-phenylpropylamine (0.85 mL) in the same manner as in Preparation Example 52.

Sources & evidence

ORD record
ord-1b57298b195d4be4aef924f4273fd517
Source dataset
uspto-grants-2014_08
Patent number
US08815920B2

Reaction notes

Loading…