1-Isopropyl-4-(4-nitrobenzyl)piperazine → 4-((4-Isopropylpiperazin-1-yl)methyl)benzenamine

Participants

Reaction Steps

A suspension of 1-isopropyl-4-(4-nitro-benzyl)-piperazine (Step 11.2) (5.7 g, 21.65 mmol) and Raney Nickel (2 g) in MeOH (100 mL) was stirred for 6 h at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 4.9 g of the title compound as a white solid: ESI-MS: 234.2.

Provenance & Evidence